Back on the Republican side, Sen. Rand Paul, R-Kentucky, told ABC News he believes the ruling on DOMA was appropriate and said the issue should be one left to the states.
As for the growing divide among Republicans on same-sex marriage, Paul said "the party is going to have to agree to disagree on some of these issues."
Rep. Paul Ryan, R-Wisconsin, said in statement that marriage is a "unique relationship between one man and one woman" and "the foundation for the family."
In a measured manner, the 2012 GOP vice presidential nominee added that he respects those with a different view and wants to carry on the conversation.
"There are honest disagreements over how we should recognize different legal arrangements," he said. "The states will now decide this issue through the democratic process."
Former Sen. Rick Santorum of Pennsylvania, an unapologetic social conservative, argued the decisions were destructive to the traditional family unit. Falling in line with other Republicans, Santorum said this kind of decision should be made by voters.
"These great moral issues of our time should be left to the democratic process, not to five activist judges," he said. "Time and time again, when the definition of marriage has been put before the people, we have affirmed the unique and irreplaceable role the union of a man and a women play in society."
He pledged to continue fighting for "a definition of marriage that gives children their birthright, a mom and a dad, and our country the best chance for a great future."