Pence, Abreu, Belt and Pablo Sandoval had two hits apiece for the Giants, who outhit the Padres 11-7.
Chris Denorfia had three hits, including a double, and Nick Hundley smacked a solo homer, his 13th, for San Diego.
NOTES: Pence started all 162 games this season, the only major-leaguer to do so. ... Playing in the final game of his 17-year career, Kotsay started in right field and went 0-for-4, capped by the strikeout against Zito. ... Padres 3B Chase Headley announced before the game that he is scheduled to undergo surgery Tuesday to repair a torn meniscus in his left knee. ... The Giants won the season series from the Padres 11-8. San Francisco prevailed in the season series against all of its NL West rivals for the third consecutive year. ... The Giants sold out every home game for a third straight season. Their season attendance total exceeded 3.3 million. ... Both teams will open the 2014 season on March 31. The Padres will host the 2013 NL West champions, the Los Angeles Dodgers, while the Giants will visit the second-place Arizona Diamondbacks.