Denver Broncos quarterback Peyton Missing did not practice with the team on Wednesday because of an ankle injury.
Manning was on the field but not participating in drills as the Broncos prepared to face the Washington Redskins on Sunday. There were no immediate reports on the extent of the injury.
The Broncos (6-1) lost for the first time this season on Sunday night, falling 39-33 to the Colts in Manning's return to Indianapolis. Manning threw for three touchdowns and one interception while completing 29-of-49 passes for 386 yards.