Ohio State freshman Ezekiel Elliott saw extensive time at running back, scoring on two touchdown runs in the third quarter and leading the Buckeyes in rushing with 162 yards on 14 carries.
Spencer caught two touchdown passes and Hall also finished with two rushing touchdowns.
Holmes had no problem with the Buckeyes continuing to score in the fourth quarter. Reserve quarterback Cardale Jones ended the bludgeoning with a 10-yard run with 1:15 left.
"We don't want a pity party," Holmes said.
NOTES: Ohio State has outscored its opponents, 122-14, in the first quarter in four games this season. ... Florida A&M's record against FBS teams fell to 1-22. Their only win was against the University of Miami in 1979. ... Coach Earl Holmes of Florida International played for the Pittsburgh Steelers and Cleveland Browns in the NFL, and was a teammate of Ohio State defensive line coach Mike Vrabel with the Steelers. ... Ohio State was 10-for-10 in the red zone entering the game, with nine touchdowns and one field goal. ... The Buckeyes' 16-game winning streak is the fifth longest in school history. The record is 22 straight from 1967 to 1969.