Tom Brady threw three touchdown passes and the New England defense made Andrew Luck look every bit like a rookie at Foxborough, Mass.

Brady threw a pair of scoring passes to tight end Rob Gronkowski as New England (7-3) won its fourth straight game. Brady also connected with Julian Edelman on a 2-yard slant at the goal line to give the Patriots a 31-17 lead early in the third quarter.

Luck threw three interceptions - two of which were returned for scores - and also lost a fumble which also led to a Patriots touchdown. He finished 27-for-50 for 334 yards with a pair of touchdown passes to T.Y. Hilton.

Trailing 14-7 early in the second quarter, the Patriots turned the game around by scoring two touchdowns in the span of a minute. Edelman returned a punt 68 yards for a score and newly acquired defensive back Aqib Talib returned an interception 59 yards for a touchdown.

Brady finished 24-for-35 for 331 yards as the Patriots scored more than 50 points for the second time this season. Indianapolis (6-4) saw its four-game winning streak come to an end.

Game notebook: Reggie Wayne reeled in seven passes. He has caught at least three passes for an NFL-leading 58 straight games. ...Patriots TE Aaron Hernandez missed the game with a nagging ankle injury. ...Brady threw a touchdown pass for the 42nd straight game. ... The game time was swtiched to 4:25 p.m. as part of television-flex scheduling. ...Gronkowski is the first tight end in NFL history to with three straight seasons of 10 or more touchdowns.