West Chester handed Kutztown its third straight loss on Saturday, beating the Golden Bears 45-24 at University Field.
Kutztown was without starting quarterback Kevin Morton during the game, who sat out due to injury.
Josh Luckenbaugh went 36-for-52 for 306 yards in Morton's place. He threw one touchdown pass and two interceptions.
Rondell White ran for 82 yards and three touchdowns for West Chester, while Mike Mattei threw for 318 yards and two scores.
The loss drops Kutztown to 1-3 on the season. The Golden Bears will travel to Slippery Rock at 6pm next Saturday.