Beltran, making his first Series appearance at age 36, singled to right for a two-run lead. The eight-time All-Star was sent to a hospital for scans Wednesday night after bruising ribs while banging into the right-field fence to rob Ortiz of a grand slam.

Beltran said he was given painkillers, and he appeared to be wearing protective padding under his jersey.

“We were all kind of sitting around waiting to see how things would turn out today,” Matheny said. “But obviously he feels pretty good. He was moving well, too.”

Matt Holliday, whose ninth-inning solo homer in the opener avoided a shutout, led off the fourth by driving a 92 mph fastball to the deepest part of Fenway Park, near the 420-foot sign below the triangle section of the bleachers in right-center. The ball hit with a thud off the low fence on the side of the Boston bullpen, ricocheting across toward straightaway center.

Matt Adams lined to second baseman Dustin Pedroia, who made a diving catch with the infield halfway in. Molina followed with a bouncer over the 6-foot-6 Lackey that was grabbed by Pedroia, who realized his only play was to first as Holliday scored.

Ortiz erased that with his 17th career postseason homer and fifth this October, pouncing when Wacha left an 85 mph changeup in the middle of the strike zone.

“We’ve got to go out there and play better than we did tonight,” Ortiz said. “Nobody can dictate that you’re going to win four straight games every time you go out there for the World Series.”

NOTES: The Red Sox had not lost in the Series since Game 7 in 1986 against the New York Mets. ... With the loss of the DH in the NL city, Farrell said Ortiz will likely play first base in Game 3. Mike Napoli would sit. ... Victims of the Boston Marathon bombings were honored during the seventh-inning stretch as singer James Taylor led the crowd in “America the Beautiful.”