The SeaWolves completed a series sweep of the Fightin Phils with a 10-1 win in Erie on Sunday.
The game marked the sixth loss in the last seven games for Reading.
Severino Gonzalez (4-6, 5.19) allowed five earned runs on nine hits and took the loss for the Fightin Phils.
Reading's only run came on an Edgar Duran home run in the ninth inning.
The Fightin Phils (29-25) will be off on Monday before opening a three-game series in Harrisburg on Tuesday.