The Sea Wolves scored a late run to beat the Fightin Phils 5-4 Monday night in their series opener in Erie.
Erie broke up a 4-4 tie with an RBI groundout in the 7th inning to seal the win.
Colton Murray (0-4, 1.91) suffered the loss on the mound in relief.
Jake Fox hit his 11th home run of the year for the Fightin Phils in the loss.
Reading (41-58) will resume its series in Erie on Tuesday night at 7:05pm.