The IronPigs battled back from a 4-0 deficit Saturday night, but couldn't complete the comeback, losing its series opener to rival Scranton/Wilkes-Barre 4-3 at Coca-Cola Park.
The loss was the sixth in the last seven games for the IronPigs.
Barry Enright (3-8, 5.28) gave up two runs in the first inning and two more in the third to take the loss on the mound.
Tyler Henson, Maikel Franco, and Leandro Castro each had an RBI to pace the 'Pigs offense.
Former Major League All-Star Grady Sizemore went 1-for-4 with a walk.
The IronPigs (39-43) will conclude their weekend series with the RailRiders on Sunday at 1:35pm at Coca-Cola Park.