CB West came back and stunned Reading in overtime 60-47.
The Red Knights were outscored 27-5 in the final 7 minutes of action.
The Berks Catholic girls are moving on, having beaten Kennard Dale 41-32.
BC will play Bishop McDevitt in the quarterfinals on Saturday.
Twin Valley's historic season came to a close at the hands of Archbishop Wood, who won 58-45.