Fowler added an RBI single in the second, and Rosario extended his hitting streak to 11 games with a two-out drive in the third.
"In the first three innings, everything was off," Cloyd said.
Staked to a 5-0 lead, De La Rosa allowed three runs in the third. Chase Utley had an RBI single to right and Brown added a sacrifice fly.
De La Rosa walked three and struck out three in 6 1-3 innings.
"He's been our guy," Weiss said.
The Phillies beat the Rockies on Monday night to snap a skid of 26 games without consecutive wins, the longest drought since a 49-game stretch in 1997. But the offensive woes that have plagued the Phillies for most of the season returned and they had only three hits against De La Rosa and three relievers.
"There are not too many options," Sandberg said. "All the guys have a chance to be out there."
NOTES: Phillies RHP Roy Halladay allowed two runs in six innings for Class-A Lakewood in his second rehab start. ... Helton made his first error of the season in the third inning. ... Phillies assistant GM Scott Proefrock said RHP John Lannan is out for the season and will need surgery on his left knee. 1B Ryan Howard (knee) can start baseball activities on Thursday. Injured pitchers Mike Adams, Jeremy Horst, Joe Savery and Mike Stutes are all making progress. OF Ben Revere (foot) is off crutches. ... Colorado sends RHP Juan Nicasio (7-6, 4.94 ERA) the mound Wednesday against Philadelphia's Cliff Lee (10-6, 3.19 ERA).
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